Henoch schonlein purpura hsp is an autoimmune, multisystem, acute vasculitis of childhood commonly involving the skin, gut, joints and the kidneys. Iga vasculitis is a disease that involves purple spots on the skin, joint pain, gastrointestinal problems, and glomerulonephritis a type of kidney disorder. Is an acute immunoglobulin a igamediated disorder characterized by a generalized vasculitis involving the small vessels of the skin, the gastrointestinal gi tract, the kidneys, the joints, and, rarely, the lungs a. This smallvessel vasculitis is mediated by immunoglobulin a igacontaining immune complexes and is characterized by nonthrombocytopenic purpura, abdominal pain, arthralgias, and renal disease.
Henoch schonlein purpura hsp is a small vessel vasculitis mediated by igaimmune complex deposition. Pathologically, it can be considered a form of leukocytoclastic vasculitis that can involve not only the skin but other tissues as well. The clinical implications of adultonset henochschonelin. Henoch schonlein purpura hsp is an immunemediated vasculitis. Case history a woman of 37 was referred after developing abdominal pain, arthralgia and a purpuric rash over her buttocks and legs a. Background 1st described in 1801 by william heberden, a physician in london, who wrote about a case of a 5 year old boy with hematuria, abdominal pain, joint pains and skin rash. Hsp can affect blood vessels in the bowel and the kidneys, as well. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure.
Henoch schonlein purpura hsp is an immunologically mediated disease associating purpura plus urticaria, characteristically affecting lower limbs, buttocks, and elbows. Symptom, treatment and advice from community members. It is characterized by the clinical tetrad of nonthrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Frequently, hsp leads to abdominal pain and intestinal bleeding, renal involvement and joint pain. Their clinical manifestations included palpable purpura in 100%, subcutaneous edema in 30%, arthritisarthralgia in 78%, gastrointestinal involvement in 56% and renal abnormalities in 30%. Gastroenterology research practice 2010, article id 597648. The small vessels of the skin, joints, kidneys, and digestive organs are particularly involved. The iga deposits in vessel walls, associated with the. The result is inflammation in the microscopic blood vessels in. Children may develop arthritis inflammation of the. Henoch schonlein purpura hsp, also called immunoglobulin a vasculitis igav, is a vascular disease that primarily affects small blood vessels. In the skin, the disease causes palpable purpura small, raised areas of bleeding underneath the skin, often with joint pain and abdominal pain.
Pdf on aug 24, 2010, chetan mukhtyar and others published henoch schonlein purpura find, read and cite all the research you need on researchgate. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. Should children with henochschonlein purpura and abdominal pain be treated with steroids. Symptoms can begin in children, most commonly between the ages of 4 and 7 years, soon after an upper respiratory tract infection or a streptococcalpharyngitis sore throat infection. Gastrointestinal manifestations of henochschonlein purpura. With kidney involvement, there may be a loss of small amounts of blood and.
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